Healthcare providers historically have focused on physician-directed scoring systems and survival statistics to determine “success” in treating various conditions, cancer included. This finding was maintained over time and is an important reminder that a patient’s goals and desires change following a cancer diagnosis and must be taken into consideration when planning treatment and determining a successful outcome. While physical function was found to be worse in the sarcoma cohorts, we observed significantly improved levels of depression in these patients when compared to the US population. These differences were present in both the early and late cohorts when compared to the US population. We evaluated results from seven health domains and found significantly lower scores in the physical function and depression domains. These patients were divided into early (2 years). One hundred thirty-eight patients were included in the analysis. Our purpose was to use PROMIS to compare outcomes in patients that had undergone resection of a nonmetastatic sarcoma to the US population. This allows comparisons between rare conditions, such as sarcomas, to more common ailments, or even the United States (US) general population. With this tool, comparisons can now be made between rare conditions, such as sarcomas, and more common ailments, of the United States general population. The Patient Reported Outcomes Measurement Information System (PROMIS) is a patient-directed system that allows comparisons across medical conditions.